Emergence of recombinant forms of HIV: dynamics and scaling

October 26, 2007

The emergence of drug resistant forms of HIV often underlies the failure of current antiretroviral therapies for HIV infection. Specific mutations in the HIV genome confer resistance to individual drugs.

Recombination, a process similar to sexual reproduction in higher organisms, can accelerate the accumulation of resistance mutations by mixing the contents of distinct viral genomes and expedite the failure of therapy. The dynamics of the emergence of recombinant forms of HIV in infected individuals remains poorly understood.

In a study publishing in PLoS Computational Biology on October 26, 2007, researchers Suryavanshi and Dixit from the Indian Institute of Science, Bangalore, India present a new model of HIV dynamics that provides a detailed account of the emergence and growth of recombinant forms of HIV following infection with diverse viral genomes.

Analysis of experimental data using the model establishes the high rate of HIV recombination and elucidates the origins of scaling relationships that link the relative prevalence of recombinant forms of HIV to the overall extent of infection. The model provides a framework for predicting the development of multi-drug resistance in HIV patients.

Source: Public Library of Science

Explore further: Nanocontainers for nanocargo: Delivering genes and proteins for cellular imaging, genetic medicine and cancer therapy

Related Stories

Research casts doubt on theory of cause of chronic fatigue

March 21, 2011

A high-profile scientific paper that gave enormous hope to patients diagnosed with chronic fatigue syndrome, and even prompted some to begin taking potent anti-HIV drugs, has been largely discredited by subsequent research.

Recommended for you

How the finch changes its tune

August 3, 2015

Like top musicians, songbirds train from a young age to weed out errors and trim variability from their songs, ultimately becoming consistent and reliable performers. But as with human musicians, even the best are not machines. ...

Machine Translates Thoughts into Speech in Real Time

December 21, 2009

(PhysOrg.com) -- By implanting an electrode into the brain of a person with locked-in syndrome, scientists have demonstrated how to wirelessly transmit neural signals to a speech synthesizer. The "thought-to-speech" process ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.