Scientists study Helicobacter pylori

Dec 11, 2006

French scientists have outlined the biological role of a potassium channel in a pathogen that colonizes the stomach.

Kerstin Stingl and colleagues at the Pasteur Institute in Paris studied Helicobacter pylori, an unusual bacterium that lacks all known potassium uptake systems, but instead has one putative potassium channel, HpKchA.

They showed, for the first time, that channel is essential for potassium uptake into H. pylori at low external concentrations, and for colonization of the mucus lining of the stomach. The role of HpKchA as a bulk potassium uptake system represents an adaptation to the hostile, but competitor-free, gastric environment.

The findings follow recent reports that H. pylori is involved in several gastric pathologies, including chronic gastritis, gastric and duodenal ulcers and gastric cancer. The scientists say their study's results might have implications for drug development to treat H. pylori-associated gastric diseases.

The research appears online in The EMBO Journal.

Copyright 2006 by United Press International

Explore further: Human stem cell model reveals molecular cues critical to neurovascular unit formation

Related Stories

Polysis is marketing a plastic that turns to clay

4 hours ago

Polysis is showing a plastic that can turn to clay when heated, according to a story on DigInfo TV. Polysis is described as a specialist developer of polyurethane resins and resin products, and they are marketing haplafreely, presented with a lower- ...

Wolfram's ID project launch touts ImageIdentify function

8 hours ago

You see a picture but you cannot name it. "What animal is this?" "Hmm, sort of looks like a guitar, not a cello—what is this instrument?" The Wolfram Language Identification Project was launched on Wednesday ...

Malaysian dam project opposed by tribes gets green light

8 hours ago

Construction of a Malaysian dam that will flood a rainforested area half the size of Singapore and displace 20,000 tribespeople was given the green light Saturday by the state government, local media reported.

Typhoon Dolphin looms over Guam

8 hours ago

Typhoon Dolphin passed through the Northern Marianas today just to the north of Guam with sustained winds estimated at 95 knots (~109 mph) by the Joint Typhoon Warning Center (JTWC). The center passed through ...

Recommended for you

Scientists turn blood into neural cells

May 21, 2015

Scientists at McMaster University have discovered how to make adult sensory neurons from human patients simply by having them roll up their sleeve and providing a blood sample.

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.