Breed of mice created for leukemia study

Aug 22, 2006

A study by U.S. cancer scientists at Ohio State University shows a new strain of mice offers the first real animal model for an incurable chronic leukemia.

The mouse, called the TCL-1 transgenic mouse, develops a malignancy that closely mimics chronic lymphocytic leukemia, or CLL. The lack of such an animal model has previously hampered the development of treatments for CLL, as well as research into its causes and the changes that drive drug resistance.

"This mouse strain shares many of the molecular and genetic features of human CLL, responds to drugs typically used to treat the disease and develops drug resistance that renders treatment ineffective, as often happens in CLL patients," said principal investigator John Byrd, a professor of internal medicine.

Byrd is a specialist in CLL at Ohio State University's Arthur James Cancer Hospital and Richard Solove Research Institute.

"The strain should be extremely valuable for the development and testing of both conventional drugs and those aimed at molecular targets for CLL," he said.

The findings are published in the Aug. 15 issue of the journal Blood.

Copyright 2006 by United Press International

Explore further: Two US states order tough Ebola quarantine rules

add to favorites email to friend print save as pdf

Related Stories

Recommended for you

Two US states order tough Ebola quarantine rules

8 hours ago

New York and New Jersey on Friday ordered a mandatory quarantine for medics who treated victims of Ebola in West Africa, after the deadly virus spread to America's largest city.

NY and NJ say they will require Ebola quarantines

Oct 24, 2014

The governors of New Jersey and New York on Friday ordered a mandatory, 21-day quarantine for all doctors and other arriving travelers who have had contact with Ebola victims in West Africa.

User comments : 0