Gene's cancer role is identified

Aug 08, 2006

U.S. medical researchers say they've discovered a new cancer-promoting role for a gene potentially linked with breast, liver and other kinds of cancer.

The scientists at Harvard Medical School and Massachusetts General Hospital say their discovery that the gene YAP can transform mammary epithelial cells opens the door to understanding how a novel cell growth controlling pathway first discovered in fruit flies might be important in human cancers.

"We screened the DNA from breast cancer cells for amplifications that are associated with tumor development," said senior author Dr. Daniel Haber, a professor of medicine and director of the MGH Cancer Center. "The identification of these new potential cancer-causing genes is critical to uncovering novel pathways that drive the conversion of a normal cell to a cancerous one.

The research was conducted jointly by Haber and Joan Brugge, a biology professor at HMS.

The findings appear in the online early edition of the Proceedings of the National Academy of Sciences and will appear in the Aug. 15 print edition.

Copyright 2006 by United Press International

Explore further: Salmonella and Campylobacter show significant levels of resistance to common antimicrobials in humans and animals

add to favorites email to friend print save as pdf

Related Stories

The past, present and future of cancer

Mar 18, 2011

Leading cancer researchers reflected on past achievements and prospects for the future of cancer treatment during a special MIT symposium on Wednesday titled “Conquering Cancer through the Convergence of Science and ...

Recommended for you

Finding psychological insights through social media

19 hours ago

Social media has opened up a new digital world for psychology research. Four researchers will be discussing new methods of language analysis, and how social media can be leveraged to study personality, mental and physical ...

User comments : 0

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.