John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
"ASCO is a great venue for sharing best practices and learning about new treatment approaches - we are proud to help contribute by presenting our recent scientific work," said Andre Goy, M.D., M.S., Chairman and Director and Chief of Lymphoma, John Theurer Cancer Center. "Our researchers will keep working to improve oncology and help develop some of the newest approaches to treating cancer. This will remain a priority for our cancer center."
Among other promising research, John Theurer Cancer Center investigators reported on a phase II study of carfilzomib, a new proteasome inhibitor to treat advanced multiple myeloma; the first phase III trial of anti-metabolite clofarabine against acute myelogenous leukemia; application of a new statistical model to predict mantle cell lymphoma survival and guide treatment choices; and a comparison of disease status and satisfaction with care among chronic myeloid leukemia patients.
"The innovative research we conduct brings tomorrow's treatments to our patients today," said Andrew L. Pecora, M.D., F.A.C.P., C.P.E., Chief Innovations Officer and Professor and Vice President of Cancer Services, John Theurer Cancer Center. "We have recently expanded our capabilities through the opening of an extraordinary new research and patient care facility, and it is our belief that this will enable us to further speed the pace of discovery and be even more prolific in our scientific publications."
Highlights of the Theurer Center presentations include:
PX-171-003-A1, an open-label, single-arm, phase (Ph) II study of carfilzomib (CFZ) in patients (pts) with relapsed and refractory multiple myeloma (R/R MM): Long-term follow-up and subgroup analysis.
David S. Siegel, M.D., Ph.D. and colleagues presented findings from a phase II, single-arm open-label study of carfilzomib (CFZ), a novel, highly selective proteasome inhibitor in development for treatment of advanced multiple myeloma. Proteasome inhibitors block the actions of certain proteins (proteasomes) that cancer cells need to survive and multiply. All patients in the study were previously unresponsive to treatment with other combination therapies. Of 257 patients completing the study, the overall response rate was 24% with a median response duration of 7.4 months. The median overall survival was 15.5 months. CFZ as a standalone treatment achieved significant responses in 36% of patients who did not previously respond to treatment with bortezomib and immunomodulatory drugs, including patients with chromosomal abnormalities. CFZ was well tolerated and adverse events were manageable with no new, unexpected, or cumulative toxicities.
Survival outcomes in elderly patients with plasma cell myeloma: The three-decade Eastern Cooperative Oncology Group (ECOG) experience.
Recent landmark papers showed significant improvement in survival rates for patients under 65 years of age with plasma cell myeloma, but not for older patients. To shed new light on progress in treating older individuals, David H. Vesole, M.D., PH.D., F.A.C.P. and colleagues examined data over the last 33 years for previously untreated patients who were treated according to standard European Cooperative Oncology Group protocols during three time periods: 1988-1993, 1994-2000 and 2001-2006. Patients receiving autologous stem cell transplantation were excluded. For patients over 65 years, there was a higher overall survival in those treated 2001-2006 (39%), than in those treated 1988-1993 and 1994-2000 (26% for both groups). These gains were far less than for patients 65 and under (63% in the 2001-2006 group, 35% for 1988-1993 and 32% for 1994-2000). The authors suggest an in-depth review of a number of variables that may contribute to worse survival for older patients, in order to improve the design of future clinical trials.
A new predictive model based on age, pretreatment LDH, and post-therapy PET-CT in patients with MCL treated with dose-intensive strategies.
Anthony Mato, M.D. and a research team from John Theurer Cancer Center conducted a retrospective study examining risk factors associated with survival of patients with mantle cell lymphoma who were treated with dose-intensive strategies and/or high dose therapy with autologous stem cell transplant. The researchers developed an algorithm that enabled them to identify distinct prognostic subgroups, based on three variables: age, levels of LDH enzymes in the blood, and presence of disease on PET scans. With a median follow up at 35 months, they found that age ≥ 60 and the presence of disease on post-treatment PET-CT scans were associated with inferior survival. They state that their prognostic model integrates PET status post therapy with baseline clinical parameters, which might help in early identification of subsets of patients who might be treated with alternate strategies in order to improve outcomes.
The association between the GOELAMS MCL-PET prognostic index and survival in patients treated with rituximab-hypercvad (R-HyCVAD) or high-dose therapy with autologous stem cell rescue (HDT/ASCT).
In a retrospective, single-center study, Tatyana Feldman, M.D. and colleagues from John Theurer Cancer Center looked at the usefulness of an existing prognostic model known as "GOELAMS" in newly diagnosed mantle cell lymphoma patients treated with dose-intensive strategies or high dose therapy with autologous stem cell transplantation. Researchers examined the cases of 83 patients, median age 58, with advanced stage mantle cell lymphoma treated with one of the two therapies. The model was not validated for these patients. The authors conclude that the study highlights the need to develop and validate models that can identify patients treated with dose-intensive approaches who are at risk for poor survival.
Association between chronic myeloid leukemia (CML) treatment responses and patient satisfaction, functioning, and quality of life (QOL): Patient survey results.
Stuart L. Goldberg, M.D. and colleagues assessed patients' awareness of chronic myeloid leukemia (CML) treatment response categorizations and the association between treatment responses and satisfaction, functioning, and quality of life. Patients were invited to participate in an online survey through the Association for Cancer Online Resources; 123 responded. Nearly all reported they were in complete hematological response. In this well-educated population (96% had some college), 90% of patients were aware of the different treatment response categories. However, 71.5% felt CML patients need more information on types of responses, with the desire for information to come from their physicians (67%) versus other staff (28%) or pamphlets (24%). Patients achieving major molecular response to treatment (MMR) had higher overall self- reported health status versus patients in complete cytogenetic response (CCyR). Complete cytogenetic response is the absence of the defective chromosome that causes the disease, while major molecular response is defined as a level of .1 percent or lower of the BCR-ABL oncoprotein as measured by a more sensitive test than traditional cytogenetic analysis. The authors conclude that from the patients' perspective, achievement of MMR is an important milestone associated with improved satisfaction with their physician, medication, daily functioning, and outlook on life. Additional research is needed to assess the best ways to help patients understand different response categories.
Clofarabine plus cytarabine compared to cytarabine alone in older patients with relapsed or refractory (R/R) acute myelogenous leukemia (AML): Results from the phase III CLASSIC 1 trial.
Dr. Goldberg and researchers from multiple cancer centers reported the results of the first phase III, prospective, randomized, blinded trial to evaluate the efficacy and safety of clofarabine (CLO) in combination with ara-C compared to ara-C alone in older adult pts (≥55 yrs) with refractory acute myelogenous leukemia (AML). 320 patients were enrolled. Median overall survival was 6.6 months and 6.4 months in the CLO+ara-C and ara-C alone study arms, respectively. The authors conclude that the study demonstrates that CLO+ara-C significantly improves patients' overall remission rate and event-free survival, with the greatest benefit in six-plus month remission patients, however, these improvements did not translate into a survival benefit compared to ara-C alone. Researchers are continuing long-term survival follow-up.
Other John Theurer Cancer Center research presented at ASCO included:
- A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma. - David S. Siegel, M.D., Ph.D., et. al.
- The effect of carfilzomib (CFZ) in patients (Pts) with bortezomib (BTZ)-naive relapsed or refractory multiple myeloma (MM): Updated results from the PX-171-004 study. - David H. Vesole, M.D., PH.D., F.A.C.P., et. al.
- Interim results from PX-171-006, a phase (Ph) II multicenter dose-expansion study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDex) in relapsed and/or refractory multiple myeloma (R/R MM). - David S. Siegel, M.D., Ph.D., et. al.
- A randomized, multicenter, phase (Ph) III study comparing carfilzomib (CFZ), lenalidomide (LEN), and dexamethasone (Dex) to LEN and Dex in patients (Pts) with relapsed multiple myeloma (MM). - David S. Siegel, M.D., Ph.D., et. al.
- Vincristine sulfate liposomes injection (VSLI) "bridging" to potentially curative hematopoietic stem cell transplantation (HSCT) in adults with Philadelphia chromosome negative (Ph-) acute lymphoblastic leukemia (ALL). - Stuart L. Goldberg, M.D., et. al.
- A single-arm, open-label, multi-center study of complete molecular response (CMR) in patients with newly diagnosed Philadelphia-chromosome positive (Ph+) chronic myeloid leukemia in chronic phase (CML-CP) treated with nilotinib. - Stuart L. Goldberg, M.D., et. al.
- A phase Ib/II open-label study to evaluate the safety and efficacy of TRU-016 in combination with bendamustine versus bendamustine alone in patients with relapsed chronic lymphocytic leukemia. - Andre Goy, M.D., M.S., et. al.
- Neoadjuvant treatment of clearly resectable colorectal liver metastases. - Donald A. McCain, M.D., Ph.D.
Provided by John Theurer Cancer Center