Dekker, a member of UMMS's program in gene function and expression in the department of biochemistry and molecular pharmacology, studies chromosome structure, and he is credited with developing early in his career a suite of extremely powerful methodologies to probe the 3-D structure of chromosomes at remarkably high resolutions. Since then, he has developed a method of using deep sequencing that allows analysis of millions of chromosome interactions in parallel.
When nominating Dekker, UMMS professor and department chairman C. Robert Matthews emphasized that the methods have brought previously invisible aspects of chromosomes into view, opening an entirely new field of study.
"Job Dekker embodies all that one might expect in the next generation of leaders in science," Matthews said. "Job sees the big picture, he is very creative, he is ambitious and he gets things done."
Tom Misteli, a senior investigator and the chief of the National Cancer Institute's cell biology of genomes arm, echoed Matthews' sentiments in support of Dekker's award: "[He] is an extraordinary scientist in many ways. He is ingenious, persistent to a fault, creative and a big thinker. While many have shied away from tackling the big question of how genomes are organized in vivo, Job Dekker fearlessly and relentlessly developed a method to pursue the answer to a very big question. His work has changed how we study gene expression, and the methods he has developed will shape the way we study genomes for many years to come."
Dekker received his bachelor's and doctoral degrees from the University of Utrecht, the Netherlands, in 1993 and 1997, respectively. He joined UMMS after a stint as a postdoctoral fellow at Harvard University from 1998 to 2003.
His pioneering approach has garnered considerable recognition and awards, including selection as a W. M. Keck Foundation Distinguished Young Scholar in 2007.
The ASBMB young investigator award recognizes outstanding research contributions to biochemistry and molecular biology by those who have no more than 15 years postdoctoral experience. It consists of a plaque, a $5,000 prize and travel expenses to present a lecture at ASBMB's annual meeting in April in Washington, D.C.
Dekker's award lecture will be at 2:55 p.m. Tuesday, April 12, in the convention center's Ballroom C.
Provided by American Society for Biochemistry and Molecular Biology
This Phys.org Science News Wire page contains a press release issued by an organization mentioned above and is provided to you “as is” with little or no review from Phys.Org staff.