New basic technologies of intellectual cell and molecular diagnostics of tumours
Fruitful cooperation of the National Research Nuclear University MEPhI, the Blokhin Russian Cancer Research Center, and the Institute of advanced training of FMBA has resulted in new basic interdisciplinary technologies of intellectual cell and molecular diagnostics of tumours of blood systems – acute leukemias – at their early stages. The development corresponds to perspective directions of personalized and translational medicine, as molecular diagnostics is its basis. The technologies have been approbated and incorporated in clinical practice.
The technological platform of the development are integrated hardware-in-the-loop optical systems: optical microscopy at the stage of cell analysis, which determines the type of leukemia (lymphoblastic or myeloblastic) and laser ductal cytofluorometry for immunophenotyping with the usage of molecular markers at the final diagnostic stage of molecular analysis.
The obtained results allowed create and develop intellectual multipurpose systems at the minimum time and finance expenses for their adaptation to concrete conditions of practical application, considering changes of users' requirements. The results are based on the technologies of artificial intelligence (pattern recognition, knowledge bases, expert systems, decision support systems, digital processing of images, signals and data in practical tasks).
The technologies of artificial intelligence, developed in MEPhI, have been successfully applied in different fields: medicine (systems of automated diagnostics of socially important diseases (histological, cytological, hematological, ophthalmological), decision making support system in intensive-care medicine, immunology, traumatology, neurology, sports medicine); nuclear industry (control of nuclear fuel quality, fuel-element jackets of nuclear energy reactors and welded connections of fuel-element covers in mass-production), in administration (management decision making support system in the State corporation for atomic energy "Rosatom"); metallurgy and other fields.
European Scientific-Industrial Chamber (Brussels) qualified obtained results as fundamental in information technologies for medicine and industry, awarding MEPhI Department of computer medical systems (№46) with a golden medal and a certificate of honor.
The priority of the development has been confirmed by 12 patents of the Russian Federation. 2 Doctor's theses, 5 PhD ones and 7 Master's degree theses have been defended; 12 articles, indexed in Web of Science and Scopus, and 5 articles, indexed in Scopus, have been published, following the results of the research. More than 30 reports have been represented at international conferences worldwide.
The works of the Department provoked the interest of the Head of the Department at the German Cancer Research Center (Heidelberg, Germany), Professor Hans-Peter Meinzer. Following the results of his meeting with MEPhI rector M.N. Strikhanov, it was decided to create a joint international laboratory as a part of MEPhI Institute of Engineering Physics for Biomedicine.
According to the Head of FMBA of Russia, application of complex raised early cancer detection at early stage for 16 % in medical units of FMBA of Russia at NPPs of the European part of Russia, young doctors of the Blokhin Russian Cancer Research Center (work experience up to 5 years) have raised the precision of diagnostics from 70% tо 95% as the result of the complex application.
Provided by National Research Nuclear University