Investigating the role of aging and poor nutrition on colon cancer

May 8th, 2014
Two risk factors – getting older and eating poorly – are implicated in more than 80 percent of colon cancer cases in developed countries. Now, researchers at Albert Einstein College of Medicine of Yeshiva University have received a $3.2 million grant from the National Institutes of Health (NIH) to investigate how aging and poor nutrition interact to cause the mutations responsible for driving colon cancer development.

Colon cancer is the second leading cause of cancer-related deaths in the United States (behind lung cancer) and the third most common cause of cancer in men and women. According to the Centers for Disease Control and Prevention, more than 130,000 people are diagnosed with the disease each year and more than 50,000 men and women will die from it. The vast majority of these cancers occur in people 50 or older.

"We know that age is a major risk factor for all types of cancer, and we also understand that lifelong dietary habits play an extremely important role in the development of colorectal cancers," said Leonard Augenlicht, Ph.D., professor of medicine and of cell biology at Einstein, director of the Biology of Colon Cancer Program at the NCI-designated Albert Einstein Cancer Center, and principal investigator on the grant.

Dr. Augenlicht has used mouse models to replicate how a Western-style diet affects the colon. Such diets are high in fat and low in levels of vitamin D, calcium and fiber. Not only did the diet cause a notable increase in the incidence of sporadic colon cancer in mice, but Dr. Augenlicht also saw ominous changes at the cellular level well before tumors developed.

The Western Diet -- defined by fried and sweet foods, processed and red meat, refined grains and high-fat dairy products -- has been liked to colon cancer. Leonard Augenlicht, Ph.D., explains his research into how diet impacts the colon and the development of the disease. Dr. Augenlicht is director of Einstein's Biology of Colon Cancer Program and a professor of medicine and of cell biology at Einstein. Credit: Albert Einstein College of Medicine
Those changes were observed within intestinal crypts – glands embedded in the wall of the small intestine. The crypts give rise to cells that absorb nutrients and that protect it from harmful substances, including the bacteria residing in the intestine. The crypts also house stem cells, which make daughter cells that travel from the crypts to repopulate and restore the intestine's mucosal lining.

Dr. Augenlicht's lab recently found that when mice are fed a Westernized diet, the crypts undergo an inflammatory response that seems to cause their stem cells to accumulate mutations. In addition, the daughter cells of these stem cells tend to stay within the crypt rather than travel into other portions of the intestinal lining – which may be a sign that stem-cell mutations were accumulating in them. Aging is also implicated in mutations, so the combination of a Westernized diet and getting older would increase the probability of colon tumors arising from mutated intestinal cells.

The Einstein researchers will use several novel techniques to find how age and diet interact to produce the intestinal stem-cell mutations that appear to be key players in causing colon cancer. One of those techniques was developed by Jan Vijg, Ph.D, professor and chair of genetics, professor of ophthalmology & visual sciences, and the Lola and Saul Kramer Chair in Molecular Genetics at Einstein and a key co-investigator on the renewed grant. Known as single-cell whole-genome sequencing, this technique will determine both the quantity and types of mutations that affect stem cells of the intestinal crypts.

"Our aim is to better understand how tumors develop and to come up with new approaches for preventing colon cancer and detecting it early," said Dr. Augenlicht.

Provided by Albert Einstein College of Medicine

This Phys.org Science News Wire page contains a press release issued by an organization mentioned above and is provided to you “as is” with little or no review from Phys.Org staff.

More news stories

Lyman-alpha emission detected around quasar J1605-0112

Using the Multi Unit Spectroscopic Explorer (MUSE) instrument astronomers have discovered an extended and broad Lyman-alpha emission in the form of a nebula around the quasar J1605-0112. The finding is reported February 9 ...

'Ultramassive' black holes discovered in far-off galaxies

Thanks to data collected by NASA's Chandra X-ray telescope on galaxies up to 3.5 billion light years away from Earth, an international team of astrophysicists has detected what are likely to be the most massive black holes ...

Using organoids to understand how the brain wrinkles

A team of researchers working at the Weizmann Institute of Science has found that organoids can be used to better understand how the human brain wrinkles as it develops. In their paper published in the journal Nature Physics, ...

Augmented reality takes 3-D printing to next level

Cornell researchers are taking 3-D printing and 3-D modeling to a new level by using augmented reality (AR) to allow designers to design in physical space while a robotic arm rapidly prints the work.

Cracking the genetic code for complex traits in cattle

A massive global study involving 58,000 cattle has pinpointed the genes that influence the complex genetic trait of height in cattle, opening the door for researchers to use the same approach to map high-value traits including ...