Flexible, biodegradable and wireless magnetoelectric paper for simple in situ personalization of bioelectric implants

These are made from nanoscale functional materials, and thus can be further customized using simple methods, such as rolling, cutting, inward folding, and outward folding without losing functionality.

The research team expects that these results with unprecedented design flexibility can lay a foundation for the low-cost, simple, and rapid personalization of temporary bioelectronic implants for minimally invasive wireless stimulation therapies.

The work is published in the journal Advanced Materials.

Implanted electrical stimulation devices are crucial for promoting neuronal activity and tissue regeneration through electrical stimulation. Therefore, these devices are essential for treating various neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease.

However, most of the state-of-the-art bioelectronic implants require rigid and bulky electronics that are mechanically incompatible with the delicate structure of nerves and other tissues, making it difficult to freely change into various sizes and shapes in real time.

In addition, the need for wire connections, battery replacement, and post-treatment removal surgeries can raise the risk of infection and make clinical treatments complex.

Left: photograph of the implantable, wireless bioelectronic paper (thickness ≈50 µm; scale bar, 3 cm), fabricated via integrating MEN into NF. The microstructure of the bioelectronic paper can be designed to random or aligned fiber orientation. Right: photographs of the bioelectronic paper tailored into various macrostructures and scales using simple rolling, origami, and kirigami techniques. Sequential images showing dissolution of the bioelectronic paper during immersion in PBS at 37.5°C. Credit: Advanced Materials (2024). DOI: 10.1002/adma.202311154

Schematic illustration of MEN synthesized in core/shell structure that couples magnetostrictive core that transduces magnetic field into local strain and piezoelectric shell that transduces strain into electric field. The MEN-NF has high porosity that allows permeation of small molecules and controllability in microstructural fiber orientations. Credit: Advanced Materials (2024). DOI: 10.1002/adma.202311154

Schematic images showing the macrostructure programming of MEN-NF bioelectronic paper. Credit: Advanced Materials (2024). DOI: 10.1002/adma.202311154