Agguttinni means "where the prevailing wind occurs" in the Inuktitut local dialect. The park includes important bird areas, key habitats for polar bears and caribou, and numerous important Inuit cultural sites. It is very remote: No roads lead to it, and access is only by helicopter, boat in the summer, or snowmobile in the winter.

During the development of the park's management plan, a team from the Canadian Museum of Nature, led by Dr. Lynn Gillespie, inventoried the park's plants and lichens in partnership with Nunavut Parks and Special Places.

Over five weeks in the summer of 2021, Dr. Gillespie's team traveled across Agguttinni, exploring the vicinity of four base camps in the park on foot and further afield by helicopter. Across this large area, they studied many different habitats from the interior Barnes Ice Cap to the coast of Baffin Bay.

The heads of the long fiords, sheltered far inland, hosted the greatest plant diversity in the park, including numerous species rare on Baffin Island and two species previously only known from farther south in Canada: Lapland diapensia (Diapensia lapponica) and flame-tipped lousewort (Pedicularis flammea). Conversely, the interior plateau near the ice cap was less diverse, but still held new records for Nunavut, such as powdered matchstick lichen (Pilophorus caerulus), Starke's fork moss (Kiaeria starkei) and sprig moss (Aongstroemia longipes).