It was the same for pathogens, according to historian Alfred W. Crosby and his influential book "The Columbian Exchange." Diseases like smallpox and measles, brought to the Western Hemisphere by the invaders, soon killed almost the entire Indigenous population. In return, Europeans fell prey to syphilis, a venereal disease they picked up from the native people. Crosby's idea about the exchange of diseases was an interesting one and it made for a good story, suggesting that with the arrival of syphilis in Europe justice of a sort had been done.

The only problem is that this syphilis scenario is wrong, according to ongoing research by paleopathologists, scientists who study skeletal remains for evidence of disease. After decades of painstaking work, they have concluded that the syphilis-causing spirochete bacterium Treponema pallidum already existed in the Old World long before Columbus boarded his ship and sailed to Hispaniola.