New method knocks out yeast genes with single-point precision

How do you make yeast work harder? Not to make bread, but in processes that yield chemicals and pharmaceuticals. Industries currently use a yeast called Saccharomyces cerevisiae. They'd like it to work better. The answer ...

Profiling the genome hundreds of variations at a time

Geneticists have been using model organisms ranging from the house mouse to the single-cell bakers' yeast, Saccharomyces cerevisiae, to study basic biological processes that regulate human development and physiology, and ...

Biophysicists unravel exact folding of a single gene

The way genes are folded determines their activity in our body. Leiden University biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature's Scientific Reports.

Genetically modified E. coli pump out morphine precursor

A common gut microbe could soon be offering us pain relief. Japanese bioengineers have tweaked Escherichia coli genes so that they pump out thebaine, a morphine precursor that can be modified to make painkillers. The genetically ...

How does a mobile DNA sequence find its target?

To understand how transposable elements shape genomes, where they are maintained over generations, it is vital to discover the mechanisms behind their targeted integration. Researchers from the Laboratoire Pathologie et Virologie ...

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