Sex chromosomes—why the Y genes matter

Several genes have been lost from the Y chromosome in humans and other mammals, according to research published in the open access journal Genome Biology. The study shows that essential Y genes are rescued by relocating to ...

Scientists unveil sex-linked control of genes

Many proteins interact with an RNA molecule called Xist to coat and silence one X chromosome in every female cell. Learning how genes are targeted and silenced may help researchers studying sex-specific diseases.

The battle of Xs: MOF complexes mediate genetic fair play

Sexually dimorphic animals are often distinguished by unequal number of the X-chromosomes. While males have only one X chromosome, females have two copies, prompting an evolutionary pressure for compensatory mechanisms against ...

Evolution of diverse sex-determining mechanisms in mammals

Scientists historically have argued that evolution proceeds through gradual development of traits. But how can incremental changes apply to the binary switch between two sexes, male or female? Researchers at Case Western ...

Undoing a hairpin doubles gene activity

Male fruit flies have one X chromosome per cell, females have two. So genes on the male X must work twice as hard to produce the same amount of protein as its female counterparts. An LMU team has found a new switch involved ...

Molecular monkey arranges X-chromosome activation

X chromosomes are very special genetic material. They differ in number between men and women. To achieve equality between sexes, one out of two X chromosomes in women is silenced. In flies, the opposite happens: in male flies, ...

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