X chromosome: How genetics becomes egalitarian

In cell biology, men and women are unequal: men have an X chromosome, while women have two. How can we get around this difference? Geneticists from the University of Geneva (UNIGE), Switzerland, turned to some historic research ...

X chromosome inactivation

Each cell in a woman's body contains two X chromosomes. One of these chromosomes is switched off, because nobody can live with two active X chromosomes. Hendrik Marks and Henk Stunnenberg, molecular biologists at Radboud ...

Sex chromosomes—why the Y genes matter

Several genes have been lost from the Y chromosome in humans and other mammals, according to research published in the open access journal Genome Biology. The study shows that essential Y genes are rescued by relocating to ...

Scientists unveil sex-linked control of genes

Many proteins interact with an RNA molecule called Xist to coat and silence one X chromosome in every female cell. Learning how genes are targeted and silenced may help researchers studying sex-specific diseases.

The battle of Xs: MOF complexes mediate genetic fair play

Sexually dimorphic animals are often distinguished by unequal number of the X-chromosomes. While males have only one X chromosome, females have two copies, prompting an evolutionary pressure for compensatory mechanisms against ...

Calico cats inspire X chromosome research

Calico cats, renowned and beloved for their funky orange and black patchwork or "tortoiseshell" fur, can thank X chromosome inactivation or "silencing" for their unique look.

Evolution of diverse sex-determining mechanisms in mammals

Scientists historically have argued that evolution proceeds through gradual development of traits. But how can incremental changes apply to the binary switch between two sexes, male or female? Researchers at Case Western ...

Undoing a hairpin doubles gene activity

Male fruit flies have one X chromosome per cell, females have two. So genes on the male X must work twice as hard to produce the same amount of protein as its female counterparts. An LMU team has found a new switch involved ...

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