How does an intestinal microbe become a pathogen?

The bacterium Escherichia coli is found in the human intestine, and elsewhere. There it is harmless, but in certain conditions it can become a pathogen. It can cause bladder infections or even sepsis. A team of researchers ...

Artificial intelligence takes structural biology to the next level

A scientist at Karolinska Institutet reports that machine learning can be used to gain insights into molecular events that change the shape of proteins after they are made, regulating their ability to interact with each other. ...

Study unravels the structure of bacterial P pili

A research team led by David Thanassi, Ph.D., of Stony Brook University, has used molecular biology and cryoelectron microscopy to successfully unravel the structure of bacterial appendages called P pili. These pili are deployed ...

Organoid bladders reveal secrets of UTIs

Urinary tract infections (UTIs) are among the most common bacterial infections. They usually require treatment with antibiotics, and almost a quarter of treated cases lead to recurrent infection. The vast majority of UTIs ...

A new avenue for fighting drug-resistant bacteria

A small regulatory RNA found in many problematic bacteria, including Escherichia coli, appears to be responsible for managing the response of these bacteria to environmental stresses. Professor Charles Dozois from Institut ...

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