SciLifeLab and AstraZeneca use cryo-EM to advance biomedicine

A study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signalling complex, the study ...

Molecular scissors stabilize the cell's cytoskeleton

Researchers at the Paul Scherrer Institute PSI in Villigen, Switzerland, have for the first time elucidated the structure of important enzymes in human cells that alter essential building blocks of the cellular cytoskeleton. ...

A light-activated remote control for cells

What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal ...

How microvilli form

The gut is lined by cells containing brush borders, which are composed of arrays of microvillar protrusions that help in nutrient absorption and provide a barrier against pathogens and toxins. Microbes such as E. coli can ...

Making the oxygen we breathe, a photosynthesis mechanism exposed

Arguably, the greatest fueler of life on our planet is photosynthesis, but understanding its labyrinthine chemistry, powered by sunlight, is challenging. Researchers recently illuminated some new steps inside the molecular ...

Unexpected finding solves 40-year old cytoskeleton mystery

Scientists have been searching for it for decades: the enzyme that cuts the amino acid tyrosine off an important part of the cell's skeleton. Researchers of the Netherlands Cancer Institute have now identified this mystery ...

Nanoshells could deliver more chemo with fewer side effects

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside ...

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