SciLifeLab and AstraZeneca use cryo-EM to advance biomedicine

A study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signalling complex, the study ...

A light-activated remote control for cells

What if doctors had a remote control that they could use to steer a patient's own cells to a wound to speed up the healing process? Although such a device is still far from reality, researchers reporting in the ACS journal ...

How microvilli form

The gut is lined by cells containing brush borders, which are composed of arrays of microvillar protrusions that help in nutrient absorption and provide a barrier against pathogens and toxins. Microbes such as E. coli can ...

Nanoshells could deliver more chemo with fewer side effects

Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside ...

Receptor tyrosine kinases control mechanosensors

Researchers at the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) have identified a role of receptor tyrosine kinases in the regulation of the cellular mechanosensory machinery, which has relevance ...

A new model for transmembrane cell-surface receptor activation

"This 'rotation model', which made the cover of BioEssays, represents a true paradigm shift in the membrane receptor field," stated Prof. Pierre De Meyts, a renowned researcher of insulin and receptor binding for almost half ...

Enzyme helps detect foreign DNA

The human immune system responds to DNA from pathogens by triggering the production of a defense molecule known as interferon. A research team led by A*STAR scientists has now pinpointed an enzyme integral to this process, ...

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