New therapeutic approach to combat African sleeping sickness

Scientists working in a range of disciplines joined forces to identify a new approach to combat African sleeping sickness. Fundamental research undertaken under the supervision of Professor Ute Hellmich of Johannes Gutenberg ...

Sleeping sickness parasite uses multiple metabolic pathways

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a study published December 27 in the open-access journal PLOS Pathogens by David Horn of ...

A very special protein synthesis machinery

Sleeping sickness-causing parasites contain an unusual protein synthesis mechanism. A team of researchers from ETH Zurich and the University of Bern have resolved its very special structure for the first time. Ribosomes are ...

Discovery aids disease elimination efforts

Researchers at the University of Dundee have identified a new drug target in parasites that cause major neglected tropical diseases, a discovery that contributes towards a global drive to eliminate these diseases by 2030.

Sleeping sickness parasites camouflage themselves with sugar

It has long been known that the pathogens causing sleeping sickness evade the immune system by exchanging their surface proteins. But now scientists at the German Cancer Research Center (DKFZ) have found an additional parasite ...

How Nagana is carried by tsetse flies

Researchers at the University of Bristol have revealed new details on how the animal disease Nagana is spread by tsetse flies in Africa.

New weakness discovered in sleeping sickness pathogen

Trypanosomes are single-celled parasites that cause diseases such as human African sleeping sickness and Nagana in animals. But they are also used in basic research as a model system to study fundamental biological questions. ...

Unusual protein production found in trypanosome mitochondria

Mitochondria, the power plants of the cell, have their own protein factories, although the cell apparatus could easily do the job for them. A special species of eukaryotes even has all the transfer-RNA it needs for protein ...

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