New cryo-EM images shed light on Wnt signaling

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and crucial for Wnt signaling activation. The findings, reported ...

Could tiny devices made out of DNA treat cancer?

One of the most promising avenues in treating cancer is to restore our immune system's ability to recognize and attack cancerous cells. A team of University of Chicago chemists and biologists developed a tiny device that ...

The importance of DNA compaction in tissue formation

Scientists led by Dr. Salvador Aznar-Benitah, head of the Stem Cells and Cancer laboratory at IRB Barcelona, have described the alterations that occur during mammary gland formation when heterochromatin (the part of DNA that ...

Undruggable diseases gain a new RNA drug-discovery tool

Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some 'undruggable' diseases, including a type of metastatic ...

Visualizing differences in RNA biology between single cells

A longstanding quest in medicine has been to understand how the same disease presents differently among various patients. Although it has been thought that a central aspect of these differences is a heterogeneity between ...

Revealing the path of a metallodrug in a breast cancer cell

Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic ...

page 1 from 2