Protecting the genome from transposon activation

Transposons are foreign DNA elements capable of random insertion into the genome, an event that can be very dangerous for a cell. Their activity must be silenced to maintain genomic integrity, which is primarily achieved ...

Scientists investigate epigenetic impact across whole genome

All life depends on a genome, which acts as an instruction manual for building all the products essential for development and survival. But knowing which of these individual instructions—or genes—need to be read, and ...

Research team spins the Sleeping Beauty transposase

EMBL scientists have developed a new variant of the so-called Sleeping Beauty transposase. It has dramatically improved biochemical features, including enhanced stability and intrinsic cell penetrating properties. This transposase ...

Upcycling of proteins protects DNA from parasites

Of the three billion base pairs in the human genome, less than two percent contain the information encoding the ~20,000 proteins. That is, because at least half of our genetic material originated from selfish genetic elements ...

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