Some of the toughest challenges in treating disease are presented by "undruggable" proteins whose structures and roles in disease are known but are seemingly unable to be targeted by drugs that will bind to them. Researchers ...
Molecular & Computational biology
Nov 21, 2022
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33
Hypoxia (oxygen deficiency), in addition to occurring in areas of considerable altitude, is a critical factor linked to various cardiopulmonary diseases of high morbidity and mortality in humans. The carotid body, a highly ...
Cell & Microbiology
Nov 3, 2022
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25
For decades, cancer researchers have longed for a way to target a set of proteins called transcription factors. While we've long known that tumors use these proteins to grow out of control, their unique configurations meant ...
Biotechnology
Nov 3, 2022
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14
Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.
Biotechnology
Nov 1, 2022
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28
National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration. The study, led by investigators at the National Human Genome ...
Cell & Microbiology
Sep 14, 2022
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61
A new study from researchers at Karolinska Institutet published in Science Advances show that inactivation of a protein complex that controls gene repression leads to loss of neuronal identity of dopamine-producing cells ...
Cell & Microbiology
Aug 29, 2022
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72
Northwestern Medicine investigators have discovered novel mechanisms underlying a specific transcription factor essential for elongation control, the process of synthesizing RNA from DNA, according to findings published in ...
Cell & Microbiology
Aug 11, 2022
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13
Unlike women, who are born with all the eggs they'll ever have, men can continue to produce sperm throughout their adult lives. To do so, they require a constant renewal of spermatogonial stem cells, which give rise to sperm.
Cell & Microbiology
Jun 23, 2022
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14
Cannabis, a plant gaining ever-increasing attention for its wide-ranging medicinal properties, contains dozens of compounds known as cannabinoids.
Molecular & Computational biology
Jun 21, 2022
1
561
Whether it's making rash decisions or feeling grumpy, hunger can make us think and act differently—"hangry," even. But little is known about how hunger signals in the gut communicate with the brain to change behavior. Now, ...
Molecular & Computational biology
May 5, 2022
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