Related topics: genes · cells · gene expression · stem cells · dna sequences

Molecular mechanism controlling fat accumulation elucidated

Scientists in Rafal Ciosk's group at the FMI have identified a novel regulator of fat accumulation in the nematode C. elegans. An RNase, REGE-1, degrades the mRNA encoding a fat loss promoting transcription factor, ETS-4. ...

Major family of gene-regulating proteins has drug-sized pocket

An entire class of proteins called transcription factors, which regulate the activity of certain genes by interacting with specific sequences of DNA, has largely been ignored by the pharmaceutical industry because it's difficult ...

Barcodes to identify gene regulators

The same DNA is present in every cell of an organism, but only some genes are expressed in a given cell. These genes are activated by proteins called transcription factors, in response to various biological signals. Transcription ...

DNA structure influences the function of transcription factors

Substances known as transcription factors often determine how a cell develops as well as which proteins it produces and in what quantities. Transcription factors bind to a section of DNA and control how strongly a gene in ...

Breakthrough in understanding how stem cells become specialized

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have made a major advance in understanding how the cells of an organism, which all contain the same genetic information, come to be so diverse. A study ...

A surplus with consequences

Why do healthy cells become malignant and proliferate uncontrollably? Scientists of the University of Würzburg have investigated the role of a special protein in this process and settled and old controversy.

Tuned gels reveal molecules that drive stem cell differentiation

By monitoring stem cell differentiation on gels that mimic the stiffness and nanofibrous structure of biological tissue, researchers have identified the specific molecules that stem cells use when selecting bone and cartilage ...

Monitoring cell fates

An international team of researchers led by ETH scientists has been studying the factors influencing the development of different blood cells. Their research shows that certain molecular mechanisms are not as relevant as ...

page 6 from 23