Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal ...
Cell & Microbiology
Jan 2, 2024
0
66
Most diseases are caused by proteins that have spun out of control. Unfortunately, so far, conventional drugs have been able to stop only a fraction of these troublemakers. A new class of drugs known as PROTACs holds great ...
Biochemistry
Dec 11, 2023
0
57
Exploring the biomedical interactions for chemical compounds and protein targets is crucial for drug discovery. Determining these drug–drug interactions (DDI) and drug–target interactions (DTI) not only reveals the potential ...
Molecular & Computational biology
Dec 5, 2023
0
23
The idea of irreversible inhibitors adhering permanently to a target protein has gained increasing attention for application in potential drug development. However, one of many hurdles is the possibility of protein mutations ...
Biochemistry
Nov 29, 2023
0
20
Methamphetamine (meth) abuse is a major health concern. Understanding how meth interacts with its target proteins is crucial for the development of novel medications to address drug addiction. Previous research into the mechanism ...
Biochemistry
Nov 24, 2023
0
53
Stanley Milgram's groundbreaking "Six Degrees of Separation" experiment demonstrated the surprisingly close connections among humans back in the 1960s. Now the research team led by Professor Matthias Mann at the Max Planck ...
Molecular & Computational biology
Nov 16, 2023
0
130
Scientists at EPFL have uncovered a cunning strategy that SARS-CoV-2, the virus that causes COVID-19, uses to increase its infectivity.
Cell & Microbiology
Nov 15, 2023
0
82
Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients. These substances are first transported as cargo to the initial sorting compartment (endosomes) before being ...
Cell & Microbiology
Sep 25, 2023
0
4
Myelotoxicity is the primary dose-limiting effect of the commonly used chemotherapeutic agent 5-fluorouracil (5-FU), which may endanger the life of the patient. Ribosome biogenesis is a key pathway regulating hematopoietic ...
Cell & Microbiology
Aug 8, 2023
0
5
The key to understanding proteins—such as those that govern cancer, COVID-19, and other diseases—is quite simple: Identify their chemical structure and find which other proteins can bind to them. But there's a catch.
Biotechnology
Aug 3, 2023
0
77
