Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...
Cell & Microbiology
Dec 8, 2022
0
56
Nucleic acid therapies involving DNA or RNA have significant potential to treat genetic disorders, infectious diseases, and cancer; however, research suggests that less than 1% of injected nucleic acid doses reach target ...
Bio & Medicine
Nov 23, 2022
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21
Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells.
Biotechnology
Nov 1, 2022
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28
Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual ...
Cell & Microbiology
Oct 10, 2022
0
208
Thanks to new RNA vaccines, we humans have been able to protect ourselves incredibly quickly from new viruses like SARS-CoV-2, the virus that causes COVID-19. These vaccines insert a piece of ephemeral genetic material into ...
Cell & Microbiology
Oct 5, 2022
0
46
Duke University researchers have developed an RNA-based editing tool that targets individual cells, rather than genes. It is capable of precisely targeting any type of cell and selectively adding any protein of interest.
Biotechnology
Oct 5, 2022
0
42
"What our work shows is how a complex in the center of the cell, the ER-Golgi interaction region, controls plasma membrane cholesterol, which is essential for many cellular functions, if not essential for multicellular life," ...
Cell & Microbiology
Sep 28, 2022
0
37
Cells are constantly making decisions that lead to differentiation. For instance, cells in an embryo make a series of decisions that determine whether they will become neurons in some cases and muscle cells in others. How ...
Biochemistry
Sep 27, 2022
0
288
As a part of our immune defenses, cytotoxic T cells—or killer T cells—seek out and destroy cells that are infected or cancerous. This process is essential for the body's defense against diseases.
Cell & Microbiology
Sep 15, 2022
0
217
Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development. Fluorescent ...
Biochemistry
Sep 8, 2022
0
89
