Sneaking up on tiny crystals with electron diffraction

Understanding the structure of proteins, the building blocks of life, is essential to obtain insight into their biological function. Due to their minute size and extreme fragility, these structures are enormously difficult ...

New sample holder for protein crystallography

Proteins are huge molecules that often have complex three-dimensional structure and morphology that can include side chains, folds, and twists. This three-dimensional shape is often the determining factor of their function ...

Gip1 structure places G proteins in lockdown

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical ...

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