Discovery of a cellular uptake pathway for larger drug molecules

Recent findings by UCSF and Arc Institute scientists open up new possibilities for overcoming a fundamental challenge in drug discovery. There can be a tradeoff between optimizing a drug's key-in-a-lock fit with its target ...

Can AI transform the way we discover new drugs?

The world's aging population, the growing burden of chronic and infectious diseases, and the emergence of novel pathogens have made the need for new treatments more urgent than ever. Yet, discovering a new drug and bringing ...

Investigating better biotransformations

Research in the International Journal of Bioinformatics Research and Applications has investigated the chemistry and behavior of a useful natural product made by the Madagascar periwinkle (Catharanthus roseus Bunge). The ...

Discovering new drugs, inspired by Darwinian theory

The body must constantly defend itself against bacteria and viruses. It generates millions of different antibodies, which are selected to recognize the enemy and trigger the best possible immune response. Scientists use these ...

High-resolution mapping method for G4 DNA structures developed

While investigating the unusual G quadruplex DNA structure (G4), the Simon Elsässer group has developed a more accurate method for mapping these structures in the genome. G4 CUT&Tag revealed numerous G4s in the human and ...

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