Pharmaceutical researchers speak of a hit when they come across a promising substance with a desired effect in early drug discovery. Unfortunately, hits are rarely bull's-eyes, often showing undesirable side effects that ...
Biochemistry
Jan 27, 2022
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92
Nanoparticles initially designed as biological markers are entering their first therapeutic trial as a treatment for patients with advanced, recurrent or refractory cancers.
Bio & Medicine
Dec 9, 2021
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18
Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The results illuminate one of ...
Molecular & Computational biology
Nov 10, 2021
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26
Cancer immunotherapy such as immune checkpoint blockade (ICB) is a revolutionary treatment against tumors by re-enforcing immune surveillance and even inducing long-term disease control.
Bio & Medicine
Sep 29, 2021
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59
Biological vesicles are nano-sized containers that transport proteins and other substances within or between cells. Most cells release so-called extracellular vesicles (EVs), which play important roles in cell-to-cell communication. ...
Molecular & Computational biology
Aug 31, 2021
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35
Tiny nano-sized robots and vehicles that can navigate through blood vessels to reach the site of a disease could be used to deliver drugs to tumors that are otherwise difficult to treat.
Bio & Medicine
May 25, 2021
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10
Molecules are the building blocks for our modern world, from phones to cars to Doritos. But coming up with new ones is still an incredibly costly and time-consuming process. A group of University of Chicago chemists wants ...
Materials Science
May 12, 2021
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20
Bowel cancer survival rates could be improved if chemotherapy drugs were delivered via tiny nanoparticles to the diseased organs rather than oral treatment.
Bio & Medicine
May 3, 2021
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16
Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, ...
Cell & Microbiology
Apr 22, 2021
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411
Matthew Kotchen, an economist at Yale University, has found that fossil fuel companies in the U.S. are getting approximately $62 billion in implicit subsidies every year. In his paper published in Proceedings of the National ...
