Cryo-EM reveals structure and mechanism of the 5-HT3 receptor

In November 2017, a Titan Krios cryo-electron microscope (cryo-EM) was inaugurated at the ESRF, the European Synchrotron, France. Data collected on this cryo-EM features in a Nature publication describing the activation cycle ...

Full-length serotonin receptor structure seen for first time

A team of researchers from Case Western Reserve University School of Medicine have used Nobel prize-winning microscope technology to see full length serotonin receptors for the first time. The tiny proteins—approximately ...

This is LSD attached to a brain cell serotonin receptor (Update)

A tiny tab of acid on the tongue. A daylong trip through hallucinations and assorted other psychedelic experiences For the first time, researchers at the UNC School of Medicine have discovered precisely what the drug lysergic ...

Scientists decode serotonin receptor at room temperature

An international research team has decoded the molecular structure of the medically important serotonin receptor at room temperature for the first time. This study reveals the dynamics of the receptor at close to its operating ...

45 years on: How serotonin makes schistosome parasites move

Schistosoma mansoni and its close relatives are parasitic flatworms that affect millions worldwide and kill an estimated 250,000 people a year. A study published on January 16 in PLOS Pathogens identifies a new part of the ...

Why acid trips last so long

Ever wondered why there have been so many urban myths and songs dedicated to LSD? Molecular dynamics (MD) simulations suggest that LSD's slow binding kinetics may be due to a 'lid' formed by extracellular loop 2 (EL2) at ...

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