Chromosomes reconfigure as cell division ends

Cellular senescence—when a cell can no longer divide—is a programmed stage in a cell's life cycle. Sometimes, as in aging, we wish it didn't happen so much and sometimes, as in cancer, we wish it would happen more. Given ...

Simulations open a new way to reverse cell aging

Research findings by a KAIST team provide insight into the complex mechanism of cellular senescence and present a potential therapeutic strategy for reducing age-related diseases associated with the accumulation of senescent ...

Despite debate, even the world's oldest trees are not immortal

The oldest trees on Earth have stood for nearly five millennia, and researchers have long wondered to what extent these ancient organisms undergo senescence, physically deteriorating as they age. A recent paper studying ginkgoes, ...

RNA provides clues to explain longevity of ginkgo trees

A team of researchers affiliated with several institutions in China and one in the U.S. has found that ginkgo biloba trees do not experience senescence. In their paper published in the Proceedings of the National Academy ...

Are our wild animals growing old gracefully?

For most of us, the body's deterioration is an unavoidable part of getting older. This age-related decline, known as "senescence", can occur subtly and slowly for some individuals, while for others it happens much faster. ...

Key protein implicated in negative side effects of senescence

Cellular senescence is a state in which normal healthy cells do not have the ability to divide. Senescence can occur when cancer-causing genes are activated in normal cells or when chemotherapy is used on cancer cells. Thus, ...

Aging cells lose their grip on DNA rogues

(Phys.org)—Transposable elements are mobile strands of DNA that insert themselves into chromosomes with mostly harmful consequences. Cells try to keep them locked down, but in a new study, Brown University researchers ...

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