DNA replication machinery captured at atom-level detail

July 15, 2019) Life depends on double-stranded DNA unwinding and separating into single strands that can be copied for cell division. St. Jude Children's Research Hospital scientists have determined at atomic resolution the ...

How host-cell enzymes combat the coronavirus

Host-cell enzymes called PARP12 and PARP14 are important for inhibiting mutant forms of a coronavirus, according to a study published May 16 in the open-access journal PLOS Pathogens by Stanley Perlman of the University of ...

Frog eggs help researchers understand repair of DNA damages

The DNA replication process in which cells divide to create new cells also triggers repair of DNA damage, researchers from the University of Copenhagen report in a new study. The researchers studied extracts from frog eggs, ...

Could villains clone themselves to take over the world?

If asked about clones, most people think of evil sci-fi characters. However, in real life, the word "clone" often has broader, far more positive applications. Just as office workers replicate documents by using copy machines, ...

Researchers discover key mechanism of DNA replication

Researchers from Osaka University in Japan have uncovered a key control mechanism of DNA replication with potential implications for better understanding how cells maintain genetic information to prevent diseases or cancer.

Finding the proteins that unpack DNA

A new method allows researchers to systematically identify specialized proteins that unpack DNA inside the nucleus of a cell, making the usually dense DNA more accessible for gene expression and other functions. The method, ...

Excessive DNA replication and its potential use against cancer

DNA over-replication is a phenomenon that can have devastating consequences for proliferating cells. When parts of the genome are duplicated more than once, cells suffer from 'genomic instability' (alterations to the structure, ...

Hijacking the double helix for replication

For years, scientists have puzzled over what prompts the intertwined double-helix DNA to open its two strands and then start replication. Knowing this could be the key to understanding how organisms - from healthy cells to ...

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