Researchers from City of Hope, one of the largest cancer research and treatment organizations in the United States, have identified how a protein receptor targeted by about 33% of all federally approved medication works. ...
Biochemistry
Dec 5, 2022
0
103
A team of interdisciplinary researchers from the Institut National de la Recherche Scientifique (INRS) is hoping to identify effective COVID-19 therapeutics. With help from the Canadian Light Source (CLS) at the University ...
Biochemistry
Sep 28, 2022
0
9
A new study shows that the protein CHIP can regulate the insulin receptor more efficiently alone than in a paired state. In cellular stress situations, CHIP usually appears as a homodimer—an association of two identical ...
Cell & Microbiology
Sep 12, 2022
0
85
The initiation of the innate immune responses relies on the detection of microbes by multiple pattern recognition receptors. Among these receptors, cyclic GMP-AMP synthase (cGAS) has been identified as a major and universal ...
Cell & Microbiology
Sep 8, 2022
0
4
A study published in Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids. ...
Biochemistry
Jul 22, 2022
0
18
A set of genes that promote sweet taste sensation is also crucial for protein management during fly development, according to a new study by Eugenia Piddini of the University of Bristol, United Kingdom, and colleagues, publishing ...
Cell & Microbiology
Jul 21, 2022
0
40
Proteins are like machines. For some diseases, it can be useful to turn these machine off or on when they are too active or not active enough. One way to control switching in a protein, such as a nuclear receptor, is to put ...
Molecular & Computational biology
Jun 1, 2022
0
5
Scientists from the Max Planck Institute for Plant Breeding Research (MPIPZ) and the University of Cologne, Germany, have discovered a novel biochemical mechanism explaining how immune proteins defend plants against invading ...
Cell & Microbiology
May 20, 2022
0
70
The human body consists of trillions of cells that constantly communicate with one another. A central role in this communication process is played by receptor proteins on the cell surface. Since they often serve as drug targets, ...
Cell & Microbiology
May 6, 2022
0
24
G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, ...
Cell & Microbiology
Apr 20, 2022
0
65
