A new study reveals the molecular structure of a protein called alpha(α)Klotho, and how it helps to transmit a hormonal signal that slows aging.
What if scientists could develop an opioid-based painkiller that is not addictive and has limited side effects?
Scientists at Heptares Therapeutics have published the first high-resolution X-ray crystal structure of the complement C5a receptor (a G protein-coupled receptor, GPCR) binding a small molecule allosteric antagonist.
Danish researchers have just presented a previously unknown mechanism that inhibits the ability of cells to develop into cancer cells. Their findings have important implications for the understanding of how cancer starts, ...
Researchers have engineered an artificial protein that may block malignant properties of cancer cells as well as correct certain birth defects.
From a drug perspective, G protein-coupled receptors are the most utilised cell receptors in the body. They are uniquely accessible at the cell surface, and a third of all drugs sold in the US target them.
Using a revolutionary live-cell microscopy technique, an international team of scientist has for the first time observed individual receptors for hormones and drugs working in intact cells.
The ability to track the movements of single molecules has revealed how proteins on the surface of nerve cells control gates that turn chemical signals into electrical signals. The finding is a step forward in detailing mechanisms ...
A powerful new way of analysing how drugs interact with molecules in the body could aid the design of better treatments with fewer side-effects.
With the heightened concerns over the dangerous side effects of the once-popular antidiabetic drug Avandia, researchers at The Scripps Research Institute (TSRI) in Jupiter, Florida, are working to understand how small molecules, ...