Genetically modifying individual cells in animals

One proven method for tracking down the genetic causes of diseases is to knock out a single gene in animals and study the consequences this has for the organism. The problem is that for many diseases, the pathology is determined ...

Structure of amyloid protein offers clues to rare disease cause

Researchers at the UAB have determined the structure of amyloid fibers formed by the protein hnRNPDL-2, implicated in limb-girdle muscular dystrophy type 3, using high-resolution cryo-electron microscopy (cryo-EM). They have ...

Molecular sensor scouts DNA damage and supervises repair

In the time it takes you to read this sentence, every cell in your body suffers some form of DNA damage. Without vigilant repair, cancer would run rampant, and now scientists at the University of Pittsburgh have gotten a ...

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