MIB2 enhances inflammation by degradation of CYLD

A team of researchers at Ehime University revealed that E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. This finding was published on Sept. 20 in the Journal of Biological Chemistry.

Hook-on drugs: New delivery strategy for K-Ras disruption

"The strategy was to design the drug to be able to hook into the hole of the FTase and GGTase I, otherwise the surface of the proteins are too large and slippery," Dr. Junko Ohkanda of Shinshu University explains her strategy ...

Study probes interplay of proteins in type 2 diabetes

A hallmark of age-related diseases such as Parkinson's disease, type 2 diabetes, or Alzheimer's disease is the abnormal clumping of proteins in cells. In people with these conditions, these protein clumps can result in irregular ...

Detailed map shows how viruses infect humans

Biologists at Columbia University Vagelos College of Physicians and Surgeons have leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect. The ...

Gold adds the shine of reversible assembly to protein cages

Protein cages—capsule-like structures made up of numerous protein molecules—perform roles in nature that have inspired their application in areas such as drug delivery. Their controlled assembly is therefore of particular ...

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