Looking through MudPIT for protein interactions

The instructions of life encoded in our genes are decoded through the translation into mRNA, which then instructs the synthesis of proteins. Because mRNA translation is an essential process, it is carefully coordinated through ...

Researchers slash pre-drug screening time from years to days

Researchers at Ben-Gurion University of the Negev (BGU) and The Hebrew University of Jerusalem (HU) have developed a powerful tool that will streamline and accelerate the development of disease therapies, transforming a multi-year ...

Melting reveals drug targets in a living organism

Developing new medicines and understanding how they target specific organs often gives a crucial advantage in the fight against human diseases. An international team led by researchers at the European Molecular Biology Laboratory ...

Solving a combinatorial quandary

Why do certain proteins in the body bind with some substances, but not with others?

MIB2 enhances inflammation by degradation of CYLD

A team of researchers at Ehime University revealed that E3 ubiquitin ligase MIB2 enhances inflammation by degrading the deubiquitinating enzyme CYLD. This finding was published on Sept. 20 in the Journal of Biological Chemistry.

Hook-on drugs: New delivery strategy for K-Ras disruption

"The strategy was to design the drug to be able to hook into the hole of the FTase and GGTase I, otherwise the surface of the proteins are too large and slippery," Dr. Junko Ohkanda of Shinshu University explains her strategy ...

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