New CRISPR-Cas9 variants can respond to viral proteases

Using a technique called circular permutation, researchers at the University of California Berkeley have created a new suite of Cas9 variants called Cas9-CPs, which will simplify design of Cas9-fusion proteins for diverse ...

A molecular hammock for cotranslational modification

Proteins do most of the real work in cells and are modified in accordance with functional requirements. An LMU team has now shown how proteins are chemically altered on the ribosome, even before they fold into the active ...

Scientists extend mechanism for cracking biochemical code

Since the time of ancient Egypt, humans have been making and breaking secret codes to retain and gain critical information. Human life itself is based upon a genetic code of DNA or RNA sequences which cells read and translate ...

Novel histone modifications couple metabolism to gene activity

Scientists of Helmholtz Zentrum München and Ludwig-Maximilians-Universität Munich (LMU) have discovered that two new classes of histone modifications couple cellular metabolism to gene activity. The study was published ...

Plant regulatory proteins 'tagged' with sugar

New work from Carnegie's Shouling Xu and Zhiyong Wang reveals that the process of synthesizing many important master proteins in plants involves extensive modification, or "tagging" by sugars after the protein is assembled. ...

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