New evidence of biochemical states and force working in concert

Inside the leading edge of a crawling cell, intricate networks of rod-like actin filaments extend toward the cell membrane at various angles, lengthening protein by protein. Upon impact, the crisscrossing rods glance off ...

Revealing atomistic structures behind AFM imaging

Atomic force microscopy (AFM) allows us to visualize the dynamics of single biomolecules during their functional activity. All observations are, however, restricted to regions accessible by a fairly big probing tip during ...

Chemists reveal how tau proteins form tangles

One of the hallmarks of Alzheimer's disease is the presence of neurofibrillary tangles in the brain. These tangles, made of tau proteins, impair neurons' ability to function normally and can cause the cells to die.

New study characterizes behavior of human plastins in cells

A family of proteins that have a role in ensuring many types of cells move and maintain their shape may promote disease when they act like workaholics and disrupt the cellular environment, new research suggests.

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