Bcl-2 family proteins are highly conserved molecules that play a crucial role in regulating the release of apoptotic proteins from mitochondria. They possess Bcl-2 homology (BH) domains, which are characterized by both sequence ...
Cell & Microbiology
Oct 19, 2023
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19
Signal transduction and perception regulates biological activities to adapt to changing environments. The Pert-Arnt-Sim domains are commonly available sensors found across diverse receptors in bacteria, eukaryotes, and archaea. ...
A team of investigators in the laboratory of Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, have discovered a novel protein region responsible for regulating ...
Cell & Microbiology
Jul 14, 2023
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25
During cell division, chromosomes, i.e., molecules containing our genetic material, must be properly replicated and segregated so that each daughter cell receives a complete and accurate set. Now, in an article published ...
Cell & Microbiology
Jun 8, 2023
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77
Collagen is the protein that holds our body together. It is produced inside cells, from where it must be transported to its site of action in connective tissue. The protein domain that is responsible for the recognition of ...
Biochemistry
May 22, 2023
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7
Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.
Cell & Microbiology
Apr 17, 2023
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19
Researchers at Baylor College of Medicine and collaborating institutions report in the journal Nature Communications how a mutation in the enzyme SKD3 can cause a form of a genetic disease known as 3-methylglutaconic aciduria ...
Cell & Microbiology
Apr 11, 2023
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18
The Allain (IBC), Gossert (BNSP) and Leitner (IMSB) groups investigated the druggability of the SARS-CoV-2 Nucleocapsid protein RNA interactions by a hybrid structure determination approach, which led to the identification ...
Molecular & Computational biology
Apr 3, 2023
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1
CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital have used a next-generation protein degradation technology to study ...
Biotechnology
Jan 25, 2023
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22
Some of the toughest challenges in treating disease are presented by "undruggable" proteins whose structures and roles in disease are known but are seemingly unable to be targeted by drugs that will bind to them. Researchers ...
Molecular & Computational biology
Nov 21, 2022
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