How cellular machinery labels proteins for degradation

Proteins are molecular work horses in the cell that perform specific tasks, but it is essential that the timing of protein activities is exquisitely controlled. When proteins have fulfilled their tasks, their degradation ...

New findings on the recycling centres of cells

Both animal and plant cells depend on autophagy in which damaged or superfluous cell material is removed. The degradation of substrates is done by proteins. In animals, it takes place in a cell organelle called the lysosome ...

Hitchhikers hinder medication shelf life

Why some biopharmaceuticals have a longer shelf life than others is a problem that has baffled scientists and manufacturers alike. Even the same medication, produced by different manufacturers, can vary in its storage life.

The birth and death of proteins in a single cell

The amount of proteins inside cells fluctuates over time, and this affects various functions of the cells. Cells are constantly synthesizing and degrading proteins, and studies have shown that this "see-saw" effect actually ...

An RNA TREAT for Halloween

Jeff Chao, Junior group leader at the FMI, and his group developed a sophisticated method to measure mRNA degradation in single cells. They developed a fluorescent biosensor that allows the distinction of intact transcripts ...

Scientists discover a key signal in intercellular communication

A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), led by Prof. Francisco Sánchez-Madrid, has characterized a cell signal that impedes intercellular communication and could ...

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