Order from disorder in the sarcomere

Alpha-actinin can cross-link actin filaments and anchor them to the Z-disk in sarcomeres. Sarcomeres are a structural unit of myofibril in striated muscle. The FATZ (filamin, α-actinin- and telethonin-binding protein of ...

RNA: A new method to discover its high-resolution structure

The structure of a biomolecule can reveal much about its functioning and interaction with the surrounding environment. The double-helical structure of DNA and its implications for the processes of transmission of genetic ...

The molecular imaging behind COVID-19 breakthroughs

It's fair to say that before the COVID-19 pandemic, very few non-scientists could name a viral protein. But now, millions of people around the world can name the SARS-CoV-2 spike protein, and a subset of those could probably ...

Revealing the way a critical enzyme works in the cell

S-acylation is the process of chemically linking a lipid to protein via a thioester bond. It is an important process of the cell that regulates the localization and function of numerous proteins. It promotes lipid membrane ...

New techniques probe vital and elusive proteins

The number of proteins in the human body, collectively known as the proteome, is vast. Somewhere between 80,000 and 400,000 proteins circulate in our cells, tissues and organs, carrying out a broad range of duties essential ...

It takes a neutron beam to find a proton

Understanding the behavior of proteins and enzymes is key to unlocking the secrets of biological processes. The atomic structures of proteins are generally investigated using X-ray crystallography; however, the precise information ...

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