New sample holder for protein crystallography

Proteins are huge molecules that often have complex three-dimensional structure and morphology that can include side chains, folds, and twists. This three-dimensional shape is often the determining factor of their function ...

The plus and minus of microtubules

Microtubules are protein polymers that assemble into dynamic structures, essential for cell division, shape, motility, and transport of intracellular cargos.

New structure for human flu virus protein

Researchers from Oxford University have worked out the molecular structure of a protein that is vital for survival of the flu virus. Recently published in Nature, they used several different techniques to look at the arrangement ...

Plan B for cholesterol transport

Cholesterol is a vital cell building block in humans and animals, and an integral part of the so-called cell membrane. This boundary layer separates the interior of the cell from the neighboring cells and the surrounding ...

New software brings lower-resolution cryo-EM maps into focus

Cryo-electron microscopy is now the most popular method for determining protein structures, which helps researchers develop drugs for different kinds of ailments. Over the last several decades, it has replaced X-ray crystallography ...

How nature builds hydrogen-producing enzymes

A team from Ruhr-Universität Bochum and the University of Oxford has discovered how hydrogen-producing enzymes, called hydrogenases, are activated during their biosynthesis. They showed how the cofactor—part of the active ...

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