Protein quality control and mitochondria

Protein aggregates are toxic for mitochondrial function, and thus disrupt the supply of chemical energy to their host cells. An LMU team has characterized a protein complex that prevents the build-up of such deposits in the ...

Misfolded proteins serve as 'inherited memory' of toxic insults

Protein aggregates have a bad reputation in conditions such as Alzheimer's disease and Parkinson's disease, but in bacteria, inheritance of aggregates by daughter cells may help protect against the same toxic stresses that ...

Trapping multidrug-resistant bacteria in molecular glue

Researchers at VIB, KU Leuven and UZ Leuven have devised a novel approach to develop antibacterial drugs. With antibiotic resistance on the rise worldwide, such new drugs are urgently needed. The Flemish biotech spin-off ...

From the omelette to the egg: Reversing protein aggregations

To cook an omelette, you have to scramble an egg, and like Humpty Dumpty it can never be put back together again. This is because the egg undergoes a set of physiological and chemical changes as it cooks, which cause its ...

Clumps as temporary storage

Researchers at ETH have discovered that the formation of protein aggregates in yeast cells is reversible. This casts new light on human diseases that can be attributed to certain protein aggregates.

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