An evolutionary method for reprogramming proteases

A team of researchers affiliated with multiple institutions in the U.S. has developed an evolutionary method for reprogramming proteases. In their paper published in the journal Science, the group describes how their technique ...

Chemical compounds in foods can inhibit a key SARS-CoV-2 enzyme

Chemical compounds in foods or beverages like green tea, muscadine grapes and dark chocolate can bind to and block the function of a particular enzyme, or protease, in the SARS-CoV-2 virus, according to a new study by plant ...

Researchers use waveguides for sensitive protease monitoring

For the first time, researchers have detected protease activity with surface-enhanced Raman spectroscopy (SERS) performed using a tiny waveguide. The work paves the way to real-time, label-free lab-on-a-chip protease monitoring, ...

How cells keep growing even when under attack

In an unexpected new finding, biochemists at the University of Massachusetts Amherst report observing that a damage-containment system in stressed bacteria can become overrun and blocked, but that this leads to cells responding ...

X-rays size up protein structure at the 'heart' of COVID-19 virus

A team of researchers at the Department of Energy's Oak Ridge and Argonne national laboratories has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease—the enzyme that enables the virus ...

Targeting SARS-CoV-2 enzyme with inhibitors

As the COVID-19 pandemic caused by the coronavirus SARS-CoV-2 continues to spread around the world, many researchers are studying epidemiological models to predict its propagation.

Expanding virophage diversity

Virophages are small viruses with double-stranded DNA genomes that co-infect eukaryotic cells along with giant viruses. Almost all known virophage genomes share only four genes in common: major and minor capsid proteins (MCP ...

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