Researchers decode targets for hundreds of signaling enzymes

When cells in the human body sense a change in the environment, molecules known as kinases can help them respond: these specialized enzymes activate proteins, propagating signals within a cell that ultimately alter its function. ...

Breakthrough discovery in mitochondrial regulation

Researchers from Osaka University identify a system known as the "GET pathway" as essential for efficient regulation of the numbers of energy-producing mitochondria

Elucidation of proteins controlling the sleep and awake transition

Professor Hiroki Ueda, Assistant Professor Daisuke Tone, Lecturer Koji Ode, and Qianhui Zhang (4th-year graduate student at the time) at the University of Tokyo showed that CaMKIIβ, a predominant protein kinase expressed ...

Decoding how plants survive drought

National University of Singapore biologists have revealed how plants suppress the formation of stomata, the microscopic pores on their surface, to limit water loss during drought conditions.

How a protein breaks free to cause deadly cancers

Better treatments for some of cancer's deadliest forms could be closer due to a University of California, Irvine-led discovery about how a certain protein is activated in tumor cells. The finding, spearheaded by researchers ...

Self-regulation of an enzyme with critical cellular functions

The lab of Kathy Gould, Louise B. McGavock Professor and professor of cell and developmental biology, used a multi-disciplinary approach that included structural biology, biochemistry, and molecular biology to investigate ...

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Phosphorylation

Phosphorylation is the addition of a phosphate (PO43-) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes.

Protein phosphorylation in particular plays a significant role in a wide range of cellular processes. Its prominent role in biochemistry is the subject of a very large body of research (as of March 2009, the Medline database returns nearly 160,000 articles on the subject, largely on protein phosphorylation).

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