Researchers elucidate the mechanics of cellular attachment

For cells to assemble into tissues and whole organs, the extracellular matrix (ECM) as well as integrins are required. The ECM forms a kind of extra-cellular protein meshwork; the integrins are surface proteins, which cells ...

Looking through MudPIT for protein interactions

The instructions of life encoded in our genes are decoded through the translation into mRNA, which then instructs the synthesis of proteins. Because mRNA translation is an essential process, it is carefully coordinated through ...

A new antiseizure target?

Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and about one-third of individuals with TLE experience seizures that do not respond to medical treatment.

Elucidating cellular responses to force

Accumulated evidence suggests that physical force plays an important role in developmental processes of fertilized animal eggs. During embryogenesis, a variety of cell populations actively migrate and change their positions, ...

Anticancer mechanism revealed in yeast experiments

Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don't get stuck. But in tumor cells, this failsafe ...

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Phosphorylation

Phosphorylation is the addition of a phosphate (PO43-) group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes.

Protein phosphorylation in particular plays a significant role in a wide range of cellular processes. Its prominent role in biochemistry is the subject of a very large body of research (as of March 2009, the Medline database returns nearly 160,000 articles on the subject, largely on protein phosphorylation).

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