Blocking cellular communication stops SARS-CoV-2

In the transmission of signals within the cell which, for example, stimulate cell growth or trigger metabolic processes, phosphate groups play an important biochemical role. The phosphate groups are often attached to proteins ...

A dual-purpose metabolic switch

Compounds called inositol diphosphates are cellular signaling "codes" involved in multiple processes ranging from phosphate sensing to DNA metabolism.

Mathematical model reveals behavior of cellular enzymes

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton University have devised a new ...

New deactivation mechanism for switch proteins detected

A new mechanism for the deactivation of switch proteins has been identified by researchers from Ruhr-Universit├Ąt Bochum, headed by Professor Klaus Gerwert and Dr. Till Rudack from the Department of Biophysics, and the University ...

New dynamic probes for ions interacting with biomolecules

Pairs of negatively charged phosphate groups and positive magnesium ions represent a key structural feature of DNA and RNA embedded in water. Vibrations of phosphate groups have now been established as selective probes of ...

Researchers observe the switching of Ras protein in detail

Ras proteins are molecular switches that decide if and when cells divide inside our bodies. An impairment of their function may result in the formation of a tumour. The process of switching the proteins on and off has been ...

Initiating DNA repair

To find out what activates SIRT6, the researchers alternately applied chemical inhibitors to human skin cells to determine which proteins were essential in getting the gene to repair the broken DNA strands. They discovered ...

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