New deactivation mechanism for switch proteins detected

A new mechanism for the deactivation of switch proteins has been identified by researchers from Ruhr-Universität Bochum, headed by Professor Klaus Gerwert and Dr. Till Rudack from the Department of Biophysics, and the University ...

New dynamic probes for ions interacting with biomolecules

Pairs of negatively charged phosphate groups and positive magnesium ions represent a key structural feature of DNA and RNA embedded in water. Vibrations of phosphate groups have now been established as selective probes of ...

Researchers observe the switching of Ras protein in detail

Ras proteins are molecular switches that decide if and when cells divide inside our bodies. An impairment of their function may result in the formation of a tumour. The process of switching the proteins on and off has been ...

Initiating DNA repair

To find out what activates SIRT6, the researchers alternately applied chemical inhibitors to human skin cells to determine which proteins were essential in getting the gene to repair the broken DNA strands. They discovered ...

How did phosphate get into RNA?

The phosphate ion is almost insoluble and is one of the most inactive of Earth's most abundant phosphate minerals. So how could phosphate have originally been incorporated into ribonucleotides, the building blocks of RNA, ...