Researchers block morphine's itchy side effect

Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. The opiate-associated itch is so common that even women who get epidurals for labor pain often ...

Study uncovers new hurdle for developing immunotherapies

The body's immune system is a valiant weapon against disease, and harnessing its power through a technique called immunotherapy is at the forefront of current research to treat cancer and other diseases.

Researchers find new signaling systems in human cells

One-third of all approved drugs target the same family of receptors: the G-protein-coupled receptors (GPCRs). Now, researchers from the University of Copenhagen, along with two American labs, have expanded the known network ...

Immunoproteasome crystal structure determined

Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...

Understanding the APJ Receptor Binding Site

(PhysOrg.com) -- Apelin is a recently discovered peptide that binds to the apelin (or APJ) G-protein-coupled receptor. Apelin-13 (NH2-QRPRLSHKGPMPF-COOH), one of several cleavage products of the proprotein form of the apelin ...

Sniffing Out the Physical Condition of Conspecifics

To date, it has been unknown exactly how mammals are capable of sniffing out whether a conspecific is ill. The biologists Prof. Marc Spehr and Daniela Flügge are following a good lead. They have discovered that a messenger ...

How to get obese mice moving -- and cure their diabetes

Mice lacking the fat hormone leptin or the ability to respond to it become morbidly obese and severely diabetic—not to mention downright sluggish. Now, a new study in the June Cell Metabolism shows that blood sugar control ...

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