Daylight hours impact opioid receptor levels in brown fat

Researchers from the Turku PET Centre, Finland, have observed that the length of daylight hours impacts opioid receptor levels in brown fat. When daylight hours shorten, the receptor activity levels elevate. A similar phenomenon ...

Pain relief without side effects and addiction

New substances that activate adrenalin receptors instead of opioid receptors have a similar pain relieving effect to opiates, but without the negative aspects such as respiratory depression and addiction.

Chemists synthesize psychotropic compound from rainforest tree

The bark of the Galbulimima belgraveana tree, found only in remote rainforests of Papua New Guinea and northern Australia, has long been used by indigenous people for both healing and ceremony. A tea brewed from the bark ...

Attacking tumours directly on identification

Theranostics, the combination of "therapy" and "diagnostics," refers to drugs that are used not only to treat tumors but also to render them visible. The principle is as simple as it is ingenious: for example, in prostate ...

New molecular probes for opioid receptors

Strong painkillers are very important in the management of patients with cancer and heart attack or requiring surgery. They extert their effect by binding to so-called opioid receptors in the body.

Next-generation single-dose antidotes for opioid overdoses

The U.S. opioid epidemic is being driven by an unprecedented surge in deaths from fentanyl and other synthetic opiates. Fentanyl's powerful effects are long-lasting, and even tiny amounts of the drug can lead to an overdose. ...

CryoEM study captures opioid signaling in the act

Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...

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