Opioid solutions found beyond the headlines

Every day, the headlines offer yet another example of how the ongoing opioid epidemic is devastating communities and individual lives. But given the significant role popular media plays in shaping public perceptions, where ...

Next-generation single-dose antidotes for opioid overdoses

The U.S. opioid epidemic is being driven by an unprecedented surge in deaths from fentanyl and other synthetic opiates. Fentanyl's powerful effects are long-lasting, and even tiny amounts of the drug can lead to an overdose. ...

New protocol for measuring background levels of drugs in crime labs

When crime lab chemists handle evidence that contains illegal drugs, trace amounts of those drugs are inevitably released into the laboratory environment. When chemists scoop a bit of powder to test it, for instance, microscopic ...

CryoEM study captures opioid signaling in the act

Opioid drugs like morphine and fentanyl are a mainstay of modern pain medicine. But they also cause constipation, are highly addictive, and can lead to fatal respiratory failure if taken at too high a dose. Scientists have ...

How computers are searching for drugs of the future

Drug discovery may bring to mind images of white lab coats and pipettes, but when Henry Lin, PhD, recently set out to find a better opioid with fewer side effects, his first step was to fire up the computers.

New study brings medicine closer to non-addictive painkillers

Powerful opiate drugs are a mainstay in modern medicine, alleviating pain in both acute and chronic forms. These charms however, bear a curse. Users quickly develop tolerance to their effects, requiring ever-increasing doses ...

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