Researchers reveal unexpected genome-wide off-target mutations caused by cytosine base editing
Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations.
Chinese scientists have found that cytosine base editors (BE3 and HF1-BE3) induce genome wide off-target mutations.
Biotechnology
Feb 28, 2019
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101
Scientists in the US have released a paper showing that they have successfully edited human embryos to correct a mutation that causes an inheritable heart condition. The findings are hugely important as they demonstrate for ...
Biotechnology
Aug 3, 2017
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28
As CRISPR-Cas9 starts to move into clinical trials, a new study published in Nature Methods has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.
Biotechnology
May 29, 2017
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14197
A new engineered version of the gene-editing CRISPR-Cas9 nuclease appears to robustly abolish the unwanted, off-target DNA breaks that are a significant current limitation of the technology, reducing them to undetectable ...
Biotechnology
Jan 6, 2016
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165