Real-time monitoring of proteins in the nuclear pore complex

In human cells, the nucleus is enclosed by a structure called the nuclear pore complex (NPC). It acts as a 'gatekeeper' controlling the transport of molecules between the nucleus and the surrounding cytoplasm (the protein-containing ...

Nanocontainers introduced into the nucleus of living cells

An interdisciplinary team from the University of Basel in Switzerland has succeeded in creating a direct path for artificial nanocontainers to enter into the nucleus of living cells. To this end, they produced biocompatible ...

Nuclear pore complex outer rings: No longer 'one size fits all'

In eukaryotic cells, the nucleus is walled off from the rest of the cell by the nuclear envelope. All transport into and out of the nucleus occurs via cylindrical channels called nuclear pore complexes (NPCs) that penetrate ...

The clouds of spaghetti that keep DNA data safe

Cells can avoid "data breaches" when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert ...

Scientists map the portal to the cell's nucleus

Like an island nation, the nucleus of a cell has a transportation problem. Evolution has enclosed it with a double membrane, the nuclear envelope, which protects DNA but also cuts it off from the rest of the cell. Nature's ...

How shuttling proteins operate nuclear pores

Nuclear pore complexes are tiny channels where the exchange of substances between the cell nucleus and the cytoplasm takes place. Scientists at the University of Basel report on startling new research that might overturn ...

Colon cancer nuclear pore dynamics are captured by HS-AFM

One of the key reasons for cancer mortality is the highly invasive behaviour of cancer cells, which is often due to aggressive metastasis. Metastasis is facilitated by various growth factors and cytokines secreted from cells ...

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